Human neoplasms develop following the progressive accumulation of genetic and epigenetic alterations to oncogenes and tumor suppressor genes. These alterations confer a growth advantage to the cancer cell, leading to its clonal proliferation, invasion into surrounding tissues, and spread to distant organs. Genes that are altered in neoplasia affect three major biologic pathways that normally regulate cell growth and tissue homeostasis: the cell cycle, apoptosis, and differentiation. While each of these pathways can be defined by a unique set of molecular (...) events, they are not biologically separate. Rather, they function more as an integrated molecular network, and perturbations in one pathway can have profound consequences on another. Insights into what distinguishes the regulation of growth and differentiation in a normal cell versus a cancer cell have led to the development of novel anticancer therapies. BioEssays 24:83–90, 2002. © 2002 John Wiley & Sons, Inc. (shrink)

As I put down my copy of The Making of Men and take up Volumes III and IV of Philosophy in Process, the period of the diary when Weiss was writing the book, I wondered whether the longer work showed more awareness of human weakness and disability. The philosophic program calls for the overcoming of bias and achievement of neutrality. Has Weiss ever admitted that men are sometimes born tired, suffer weaknesses, yield to the temptation of aiming low rather than (...) high, fail to put out much effort in capturing "the free energy" that Weiss ascribes to us all? If Weiss doesn't correct his account of human life that is too much based on his own great strengths, then the philosophy must be criticized as one-sided. Even if he has swept aside laziness as subhuman, much as a good teacher encourages students by expecting the superhuman and ignoring the subhuman, this practical encouragement cannot fully excuse theoretical failure in adequacy. For surely we who know Weiss know that he is not merely a performing artist who sometimes takes the classroom as a stage, but rather is a coach who knows how to bring the best performance out of his team of intellectual athletes. Most coaches expect to win every game and have a philosophy that never anticipates or prepares for failure. Is that why Weiss found himself so much at home in the world of Sport? (shrink)

The reputation of Rudolf Hermann Lotze was high in the philosophic world, especially the English-speaking philosophic world, during the period 1880–1920. One encyclopedia of the period says that “in the U. S. his influence is stronger in academic philosophy, perhaps, than that of any other author.” In typical histories of philosophy Lotze is counted among the great successors in the tradition of Kant and Hegel. I have elsewhere sought to explain the reasons for his great influence. Writers contemporary to Lotze (...) wanted first to classify him as an Herbartian, and in spite of his protests, he seemed some sort of Kantian or Hegelian. The character of his philosophy remained enigmatic, and he was sometimes called an “eclectic” since his philosophy contained aspects that reminded readers of some predecessor or other. But clearly he resisted the tendency to make all questions problems of knowledge: “The constant whetting of the knife is tedious, if it is not proposed to cut anything with it.” And clearly he is no Hegelian. He considered the rationalistic search for a single principle and a single method to have failed. German philosophy had failed to respect what is given in experience. Even in aesthetics, where surely one might be expected to attend to what the arts present for sensuous enjoyment, German intellectualism, to Lotze’s disgust, tended to use a deductive method. Santayana accused a priori German philosophers of “egotism”; he might have learned this from Lotze who found this same tradition marked by pretension. Only God could satisfy the program of Fichte. The demand of an all-embracing system is that it “make all particular parts of it pass before [us] in the majestic succession of an unbroken development!” Wrote Lotze, “It seemed to me that only a Spirit who stood in the centre of the universe which he himself had made could, with knowledge of the final aim which he had given his creation…” see the whole. Lotze’s kind of philosophy is professedly modest, nondogmatic, fallibilist. (shrink)

For several terms at Cambridge in 1939, Ludwig Wittgenstein lectured on the philosophical foundations of mathematics. A lecture class taught by Wittgenstein, however, hardly resembled a lecture. He sat on a chair in the middle of the room, with some of the class sitting in chairs, some on the floor. He never used notes. He paused frequently, sometimes for several minutes, while he puzzled out a problem. He often asked his listeners questions and reacted to their replies. Many meetings were (...) largely conversation. These lectures were attended by, among others, D. A. T. Gasking, J. N. Findlay, Stephen Toulmin, Alan Turing, G. H. von Wright, R. G. Bosanquet, Norman Malcolm, Rush Rhees, and Yorick Smythies. Notes taken by these last four are the basis for the thirty-one lectures in this book. The lectures covered such topics as the nature of mathematics, the distinctions between mathematical and everyday languages, the truth of mathematical propositions, consistency and contradiction in formal systems, the logicism of Frege and Russell, Platonism, identity, negation, and necessary truth. The mathematical examples used are nearly always elementary. (shrink)

This dissertation examines the conceptual limitations of Kant's ethical theory with the purpose of assessing its suitability as a model of practical philosophy based upon the idea of autonomy. My aim is not only to exhibit the specific weaknesses in Kant's treatment of morality, but also to explore a contrast between two different approaches in ethical theory. This contrast can be characterized in terms of an opposition between a 'formal-individualistic' and a 'social-historical' model for the analysis and derivation of ethical (...) principles. The crucial problem here is whether an ethical theory can be constructed on the exiguous basis of concepts such as the 'rationality' or 'freedom' of the will, or whether it requires an insight into the connection between moral principles and specific conditions of historical and social life that constitute the real foundation of moral judgment. ;The dissertation is composed of four chapters. In Chapter One I consider the deficiencies in Kant's treatment of the historical and temporal dimensions of moral volition. I focus especially upon his neglect of the conditions of historical genesis that underlie the framework of moral concepts he analyzes. In the second and third chapters I examine Kant's failure to attend to the social dimension of morality and distinguish two separate parts to this objection: difficulties resulting from his restriction of the scope of moral freedom to the domain of an agent's inner intentions, so that a consideration of the consequences of action is excluded, and problems arising from his monological interpretation of the universalization procedure. Finally, in Chapter Four I argue that Kant's neglect of the historical and social dimensions of morality is by no means accidental. Rather, it is a function of his reliance upon a two-world metaphysical framework in which moral principles are understood essentially as the laws governing a purely rational, non-natural order. The dependence of Kant's ethical theory upon 'problematic' metaphysical premises--particularly in his justification of the moral law--suggests that the two dimensions he excludes from his analysis--history and society--must be integrated within it in order to yield a more convincing elaboration of the basic concepts of morality. (shrink)

One of the most common and frustrating experiences for philosophy instructors is teaching students who have not read the assigned text prior to coming to class. This chapter proposes three specific strategies, supported by the literature on student learning, that encourages and enables students to read and understand assigned texts. Each strategy activates students’ prior knowledge, sets a purpose to read and uses novelty to engage students’ attention. Evidence from experience with these strategies is provided to further support their effectiveness. (...) The chapter concludes with examples of how strategies can be presented to students and templates that instructors can use to create their own strategies for use in any class or assigned text. (shrink)

Rock art - paintings, and pecked or engraved images on rocks, whether in caves, shelters, or in the open-air - exists in all but a couple of countries of the world [Bahn, 1998], It spans a period from at least 35,000 years ago to historic times, comprises many millions of images from hundreds of thousands of sites, and thus constitutes the vast majority of the world's art, and art history. It is a phenomenon that has seen a huge upsurge of (...) interest in the last few decades, with not only numerous publications and conferences, but also a proliferation of calendars, T-shirts, mugs, jewellery, and garments bearing rock art images. Many people who are famous for other things have worked on or published rock art - for example, scholars such as Mary Leakey or authors like Joy Adamson or Erle Stanley Gardner. Rock art studies have always been the domain of the “amateur” as well as the “professional”, and amateurs remain of huge importance in this field. Indeed, most of the principal rock art organisations, along with their journals, were created by, are run by, and consist largely of amateur enthusiasts who include some of the world's foremost specialists. The growing popularity of the art brings an ever-increasing risk of pollution, damage, and vandalism, as well as outright thefts of wall or cave images. The rock art associations are dedicated to the discovery, recording, and conservation of rock art, and play a major role in striving to teach schoolchildren and adults alike about the incalculable importance of this irreplaceable, universal heritage and about the need to respect and protect it. (shrink)

Can we know truth even though certain proof is unattainable? Can we be known by Truth? Is there a relationship between belief and truth, and if so, what is the nature of that relationship? Do we need to have faith in reason and in real meaning to be able to reason towards truth? These are the sorts of questions this book seeks to address. In Faith's Knowledge, Paul Tyson argues that all knowledge that aims at truth is always the (...) knowledge of faith. If this is the case, then--against our modernist cultural assumptions about knowledge--truth cannot be had by proof. Yet, if this is true, then mere information and simply objective facts do not (for us as knowers) exist. Knowledge is always embedded in belief, and knowledge and belief is always expressed in relationships, histories, narratives, shared meanings, and power. Hence, a theological sociology of knowledge emerges out of these explorations in thinking about knowledge as a function of faith."--Publisher's website. (shrink)

Christian Baatz argues that individuals have an imperfect duty to take reasonable steps to reduce their greenhouse gas emissions, and that governments should be working to implement st...

Effective efforts to protect the global environment will require the willing cooperation of the world's poor. Persuading them to join international environmental agreements and to choose environmentally sustainable development requires substantial concessions from the affluent industrialized countries, including additional financial assistance and technology transfers. The affluent countries ought to provide such assistance to the world's poor for ethical reasons. Doing so would promote transnational distributive justice, which is defined here as a fair and equitable distribution among countries of benefits, burdens, (...) and decision-making authority, in this case associated with transnational environmental relations. Conceptions of distributive justice examined include utilitarianism, human rights, causality/responsibility, impartiality, and principles derived from Kantian and Rawlsian ethics. (shrink)

Among controversies about philosophy that are also philosophical problems the most complex and difficult to solve is that about philosophy and the history of philosophy. On one hand there is Wittgenstein claiming that history is irrelevant to philosophy. On the other hand, there is Gilson claiming that history is not only relevant but necessary to philosophy.